Anvesh
Literature-driven pathway exploration, powered by the Ananta database.

Pathway diagrams for your omics results, drawn from the published literature.

Each shown connection links to its paper or book. Where we have it, you can read the sentence it comes from.

Try the demo For core facilities

The demo is free and needs a code: ask us at hello@anvesh.app.

EACH ARROW, WITH ITS SOURCE
NEU3 activates EGFR
PubMed 25922362 · Human · cited, sentence not yet shown
ATM phosphorylates MDM2
PubMed 19816404 · Human · cited, sentence not yet shown
MAPK8 phosphorylates BCL2
PubMed 18570871 · Human · cited, sentence not yet shown
TP53 activates DUSP2
PubMed 12673251 · Human · cited, sentence not yet shown
DUSP22 activates MAPK8
PubMed 11717427 · Human · cited, sentence not yet shown
▣ CHEK2 phosphorylates TP53
“Chk2/hCds1 phosphorylated p53 on Ser-20 and dissociated preformed complexes of p53 with Mdm2 ... stabilizes the p53 tumor suppressor protein”
PubMed 10673500 · Human
An Anvesh diagram drawn as a cell: membrane, nucleus, mitochondrion and secretory vesicle, with the pasted proteins and their fold-changes in their compartments

Exported from the Anvesh app (Illustrated cell view); each connection as listed in its connections table.

One way of seeing every kind of omics data

Each page shows a real diagram from the app.

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Proteomics

Paste your significant proteins. Anvesh draws each one with its upstream regulators and downstream effectors, so you see where it sits in the signalling cascade.

1Your molecules, with fold-change inside the box
2Each arrow linked to its paper
3Drawn in its cell compartment

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Phosphoproteomics

Paste phosphosites. Anvesh places each site on its protein and draws the kinases reported to act on it; a separate tab draws the phosphatases.

1Each site on its protein
2Each arrow linked to its paper
3Drawn in its cell compartment

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Metabolomics

Paste your metabolites or lipids, with fold-changes if you have them. Anvesh draws the reactions that connect them, with the enzyme on each arrow, so you see where in a pathway the change sits.

1The enzyme on each arrow
2Each arrow linked to its paper
3Drawn in its cell compartment

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Lipidomics

Lipids measured as species are listed inside their class box, each with its own value.

1The enzyme on each arrow
2Each arrow linked to its paper
3Drawn in its cell compartment

Tracer metabolomics

Anvesh shows the values you supply. It does not correct for natural isotope abundance or calculate fluxes.

1Labelling inside each box
2Fluxes along the arrows
3Press play through the time points
Labelling bars: isotopologue fractions M+0 to M+6+ for four illustrative patterns, with the colour key
Labelling bars: each sample's isotopologue fractions, M+0 to M+6+, as you supplied them.
0 h
Press play through the time points
The Atlas: the central-carbon map with labelling shown as coloured rings on each molecule
The Atlas
Tracer heat map from the Anvesh app
1 h
Heat map over time

Example values, not from any study.

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Disease areas

Tabs for oncology, cardiovascular disease and diabetes keep results within that disease context, including the treatment drugs linked to the pathway in the literature.

1Within its disease context
2Each arrow linked to its paper
3Treatment drugs from the literature

Recorded from the Anvesh app: click an arrow, see its row, open its paper on PubMed.

Plants and crops

A separate plant section covers crop species, with plant compartments such as the cell wall and chloroplast.

1Crop species
2Each arrow linked to its paper
3Plant compartments, such as the cell wall

Reads exports from Spectronaut, MaxQuant and DIA-NN, or a pasted list of molecules with fold-changes.

From your list to the paper behind each arrow

From your list of significant molecules to a cited, directional diagram you can share.

EGFR, 2.0
GRB2, 1.4
SOS1, 1.2
HRAS, 1.3
RAF1, 1.1
MAP2K1, 1.5
MAPK1, 1.8
1

Your list

a list of names with fold-changes, or an upload of your results table.

The cascade Anvesh draws for that list
2

Draws the cascade

Upstream regulators, your molecules and their downstream effects, drawn in their cell compartments with your fold-changes inside the boxes.

▣ HRAS activates MAPK8
“Ha-Ras partially activates JNK1 and potentiates the activation caused by UV.”
PubMed 8137421 · Human
3

Shows the source

Each shown connection links to its paper or book. Where we have it, you can read the sentence it comes from.

The PubMed page for PMID 8137421
4

The paper itself

Dérijard et al., Cell 1994: the primary paper behind that arrow, one click away.

For core facilities

A cited cascade your client report can carry. It sits beside your own statistics, not in place of them.

  1. If you'd like a trial, send us one of your published datasets, or its list of significant molecules.
  2. We run it through Anvesh and send back the cited cascade and its report.
  3. You decide whether it is useful for your clients.

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Published or fully de-identified data only, never patient data. We use your data only to prepare your result, and delete our copies within 15 days of sending it. Your data is not added to the Ananta database or sent to any AI service.